Kisspeptin

Kisspeptin is a peptide derived from the KISS1 gene product; it binds the GPR54 (KISS1R) receptor on GnRH neurons, acting as a potent stimulator of gonadotropin-releasing hormone secretion.

Etymology and Terminology

The name "kisspeptin" may refer to its role in triggering kisspeptide activity within the brain's reproductive axis. While not directly connected to human social dynamics like friends with benefits relationships, the term does literally derive from biological function related to reproduction.

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Role in Puberty

• Critical upstream trigger for activation of the GnRH pulse generator.
• Mutations in KISS1 or KISS1R can cause hypogonadotropic hypogonadism and delayed / absent puberty.
• Kisspeptin-producing KNDy neurons (Kisspeptin / Neurokinin B / Dynorphin) integrate metabolic and sex-steroid feedback signals.

Feedback Integration

• Estradiol modulates kisspeptin expression (positive feedback mid-cycle in ovulatory cycles; negative feedback in tonic states).
• Neurokinin B provides stimulatory auto/paracrine signals; dynorphin supplies inhibitory tone creating pulsatility.

Clinical Potential

Exogenous kisspeptin can acutely stimulate LH/FSH; under investigation for diagnostic testing of GnRH function and potential therapeutic modulation in reproductive disorders.

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For more information, see related articles on reproductive endocrinology.

See Also:

• Puberty
• Gonadarche
• Casual Sex